Botulinum toxin type A-induced changes in the chemical coding of dorsal root ganglion neurons supplying the porcine urinary bladder

Journal title

Polish Journal of Veterinary Sciences




No 2


Divisions of PAS

Nauki Biologiczne i Rolnicze


Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn




DOI: 10.2478/v10181-012-0053-z ; ISSN 1505-1773


Polish Journal of Veterinary Sciences; 2012; No 2


Apostolidis A. (2005), Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity, J Urol, 174, 977, ; Averill S. (1995), Immunocytochemical localization of trkA receptors in chemically identified subgroups of adult rat sensory neurons, Eur J Neurosci, 7, 1484, ; Baimbridge K. (1992), Calcium-binding proteins in the nervous system, Trends Neurosci, 15, 303, ; Biella G. (1991), Facilitatory role of calcitonin gene-related peptide (CGRP) on excitation induced by substance P (SP) and noxious stimuli in rat spinal dorsal horn neurons. An iontophoretic study in vivo, Brain Res, 559, 352, ; Birder L. (2001), Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells, Proc Natl Acad Sci USA, 98, 13396, ; Bossowska A. (2009), Distribution and neurochemical characterization of sensory dorsal root ganglia neurons supplying porcine urinary bladder, J Physiol Pharmacol, 60, 77. ; Callsen-Cencic P. (1997), Expression of neuropeptides and nitric oxide synthase in neurons innervating the inflamed rat urinary bladder, J Auton Nerv Syst, 65, 33, ; Chancellor M. (2008), Drug Insight: biological effects of botulinum toxin A in the lower urinary tract, Nat Clin Pract Urol, 5, 319. ; P. Charbel Issa (2001), Intrathecally delivered glial cell line-derived neurotrophic factor produces electrically evoked release of somatostatin in the dorsal horn of the spinal cord, J Neurochem, 78, 221, ; Chen C. (2011), Therapeutic effects of detrusor botulinum toxin A injection on neurogenic detrusor overactivity in patients with different levels of spinal cord injury and types of detrusor sphincter dyssynergia, Spinal Cord, 49, 659, ; Chuang Y. (2004), Intravesical botulinum toxin a administration produces analgesia against acetic acid induced bladder pain responses in rats, J Urol, 172, 1529, ; Coggeshall R. (1998), Ultrastructural analysis of NMDA, AMPA, and kainiate receptors on unmyelinated and myelinated axons in the periphery, J Comp Neurol, 391, 78,<78::AID-CNE7>3.0.CO;2-O ; Cui M. (2004), Subcutaneous administration of botulinum toxin A reduces formalin-induced pain, Pain, 107, 125, ; Duggan A. (1995), Afferent volley patterns and the spinal release of immunoreactive substance P in the dorsal horn of the anaesthetized spinal cat, Neuroscience, 65, 849, ; Durham P. (2004), Regulation of calcitonin gene-related peptide secretion from trigeminal nerve cells by botulinum toxin type A: implications for migraine therapy, Headache, 44, 35, ; Filippi G. (1993), Botulinum A toxin effects on rat jaw muscle spindles, Acta Otolaryngol, 113, 400, ; Giannantoni A. (2006), Botulinum-A toxin injections into the detrusor muscle decrease nerve growth factor bladder tissue levels in patients with neurogenic detrusor overactivity, J Urol, 175, 2341, ; Girard B. (2008), PACAP-mediated ATP release from rat urothelium and regulation of PACAP/VIP and receptor mRNA in micturition pathways after cyclophosphamide (CYP)-induced cystitis, J Mol Neurosci, 36, 310, ; Gottsch H. (2011), A pilot study of botulinum toxin for interstitial cystitis/painful bladder syndrome, Neurourol Urodyn, 30, 93, ; Honda C. (1995), Differential distribution of calbindin-D28k and parvalbumin in somatic and visceral sensory neurons, Neuroscience, 68, 883, ; Jabbari B. (2003), Botulinum toxin a improved burning pain and allodynia in two patients with spinal cord pathology, Pain Med, 4, 206, ; Jankovic J. (2004), Botulinum toxin in clinical practice, J Neurol Neurosurg Psychiatry, 75, 951, ; Jimenez-Andrade J. (2004), Pronociceptive role of peripheral galanin in inflammatory pain, Pain, 110, 10, ; Kakizaki H. (1996), Role of spinal nitric oxide in the facilitation of the micturition reflex by bladder irritation, J Urol, 155, 355, ; Kanagarajah P. (2012), Role of botulinum toxin-A in refractory idiopathic overactive bladder patients without detrusor overactivity, Int Urol Nephrol, 44, 91, ; Kim W. (2000), Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit tumor necrosis factor-alpha production in injured spinal cord and in activated microglia via a cAMP-dependent pathway, J Neurosci, 20, 3622. ; P. Le Greves (1985), Calcitonin gene-related peptide is a potent inhibitor of substance P degradation, Eur J Pharmacol, 115, 309, ; Li Y. (2005), An immunocytochemical study of calbindin-D28K in laminae I and II of the dorsal horn and spinal ganglia in the chicken with special reference to the relation to substance P-containing primary afferent neurons, Arch Histol Cytol, 68, 57, ; Maggi C. (1990), The dual function of capsaicin-sensitive sensory nerves in the bladder and urethra, Ciba Found Symp, 151, 77. ; Maggi C. (1997), Tachykinins as peripheral modulators of primary afferent nerves and visceral sensitivity, Pharmacol Res, 36, 153, ; Meller S. (1993), Nitric oxide (NO) and nociceptive processing in the spinal cord, Pain, 52, 127, ; Mersdorf A. (1992), Intrathecal administration of substance P in the rat: the effect on bladder and urethral sphincteric activity, Urology, 40, 87, ; Morton C. (1988), Release of immunoreactive somatostatin in the spinal dorsal horn of the cat, Neuropeptides, 12, 189, ; Neugart F. (2006), Injections of botulinum toxin a into the detrusor vesicae for treatment of refractory detrusor hyperactivity in non-neurological patients, Aktuelle Urol, 37, 212. ; Noguchi K. (1989), Prepro-VIP and preprotachykinin mRNAs in the rat dorsal root ganglion cells following peripheral axotomy, Brain Res Mol Brain Res, 6, 327, ; Raivich G. (1991), NGF receptor-mediated reduction in axonal NGF uptake and retrograde transport following sciatic nerve injury and during regeneration, Neuron, 7, 151, ; Rapp D. (2006), Botulinum toxin type a inhibits calcitonin gene-related peptide release from isolated rat bladder, J Urol, 175, 1138, ; Reitz A. (2004), European experience of 200 cases treated with botulinum-A toxin injections into the detrusor muscle for urinary incontinence due to neurogenic detrusor overactivity, Eur Urol, 45, 510, ; Sandkuhler J. (1990), Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: comparison with spinal morphine, Neuroscience, 34, 565, ; Smith C. (2003), Effect of botulinum toxin A on the autonomic nervous system of the rat lower urinary tract, J Urol, 169, 1896, ; Smith C. (2004), Botulinum toxin a has antinociceptive effects in treating interstitial cystitis, Urology, 64, 871, ; Vaughan C. (1995), Urine storage mechanisms, Prog Neurobiol, 46, 215, ; Vizzard M. (2001), Alterations in neuropeptide expression in lumbosacral bladder pathways following chronic cystitis, J Chem Neuroanat, 21, 125, ; Welch M. (2000), Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins, Toxicon, 38, 245,