Immunohistochemical evaluation of expression of heat shock proteins HSP70 and HSP90 in mammary gland neoplasms in bitches

Journal title

Polish Journal of Veterinary Sciences




No 2


Divisions of PAS

Nauki Biologiczne i Rolnicze


Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn




DOI: 10.2478/v10181-011-0135-3 ; ISSN 1505-1773


Polish Journal of Veterinary Sciences; 2012; No 2


Beckmann R. (1990), Interaction of Hsp70 with newly synthesized proteins: implications for protein folding and assembly, Science, 248, 850, ; Bongiovanni L. (2008), Apoptosis and anti-apoptotic heat shock proteins in canine cutaneous infundibular keratinizing acanthomas and squamous cell carcinomas, Vet Dermatol, 19, 271, ; Chen Y. (1999), Involvement of heat-shock protein 70 and P53 proteins in attenuation of UVC-induced apoptosis by thermal stress in hepatocellular carcinoma cells, Photochem Photobiol, 70, 78, ; Chu R. (2001), Heat shock proteins in canine transmissible venereal tumor, Vet Immunol Immunopathol, 82, 9, ; Ciocca D. (1990), Colocalization of estrogen and progesterone receptors with an estrogen-regulated heat shock protein in paraffin sections of human breast and endometrial cancer tissue, Breast Cancer Res Treat, 16, 243, ; Ciocca D. (1992), Effect of human papillomavirus infection on estrogen receptor and heat shock protein hsp27 phenotype in human cervix and vagina, Int J Gynecol Pathol, 11, 113, ; Ciocca D. (1993), Heath shock protein Hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications, J Natl Cancer Inst, 85, 570, ; Ciocca D. (1998), Heat shock proteins Hsp27 and Hsp70: lack of correlation with response to tamoxifen and clinical course of disease in estrogen receptor-positive metastatic breast cancer (a Southwest Oncology Group Study), Clin Cancer Res, 4, 1263. ; Doré M. (2003), Cyclooxygenase-2 expression in canine mammary tumors, Vet Pathol, 40, 207, ; Gamblin R. (1997), Overexpression of p53 tumor suppressor protein in spontaneously arising neoplasms of dogs, Am J Vet Res, 58, 857. ; Georgopoulos C. (1993), Role of the major heat shock proteins as molecular chaperones, Annu Rev Cell Biol, 9, 601, ; Gyrd-Hansen M. (2004), Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity, Cell Cycle, 3, 1484, ; Hadaschik B. (2008), Intravesically administered antisense oligonucleotides targeting heat-shock protein - 27 inhibit the growth of non-muscle-invasive bladder cancer, BJU Int, 102, 610, ; Havik B. (2007), Additive viability-loss following hsp70/hsc70 double interference and hsp90 inhibition in two breast cancer cell lines, Oncol Rep, 17, 1501. ; He L. (2005), Heat shock protein 70 expression in relation to apoptosis in primary bladder transitional cell carcinoma, Chin Med J (Engl), 118, 2093. ; Isomoto H. (2003), Expression of heat shock protein Hsp70 and Hsp40 in gastric cancer, Cancer Lett, 198, 219, ; Kamada M. (2007), Hsp 27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells, Mol Cancer Ther, 6, 299, ; Kumaraguruparan R. (2006), Of humans and canines: a comparative evaluation of heat shock and apoptosis-associated proteins in mammary tumors, Clin Chim Acta, 365, 168, ; Lindquist S. (1999), The heat shock proteins, Annu Rev Genet, 22, 631, ; Misdorp W. (1999), Histological Classification of Mammary Tumors of the Dog and Cat. ; Misdorp W. (2002), Tumors in Domestic Animals, 575, ; Morino M. (1997), Specific expression of HSP27 in human tumor cell lines in vitro, In Vivo, 11, 179. ; J. de Las Mulas (2005), A prospective analysis of immunohistochemically determined estrogen receptor h and progesterone receptor expression and host and tumor factors as predictors of disease-free period in mammary tumors of the dog, Vet Pathol, 42, 200, ; Nieto A. (2005), Immnohistologic detection of estrogen receptor alpha in canine mammary tumors: clinical and pathologic associations and prognostic significance, Vet Pathol, 37, 239, ; Queiroga F. (2007), Expression of Cox-1 an Cox-2 in canine mammary tumours, J Comp Pathol, 136, 177, ; Rodo A (<b>2007</b>) Expression of HER-2 receptors, E - cadherin, and p53 protein in breast cancer females. Doctoral thesis, Warsaw University of Life Sciences (SGGW). ; Romanucci M. (2005), Heat shock proteins expression in canine intraeutaneous carnifying epithelioma and squamous cell carcinoma, Vet Dermatol, 16, 108, ; Romanucci M. (2006), Heat shock protein expression in canine malignant mammary tumours, BMC Cancer, 6, 171, ; Seymour L. (1990), Tumor factors predicting for prognosis in metastatic breast cancer. The presence of P24 predicts for response to treatment and duration of survival, Cancer, 66, 2390,<2390::AID-CNCR2820661124>3.0.CO;2-A ; Soslow R. (2000), COX-2 is expressed in human pulmonary, colonic and mammary tumours, Cancer, 89, 2637,<2637::AID-CNCR17>3.0.CO;2-B ; Storm F. (1993), Heat shock protein 27 overexpression in breast cancer lymph node metastasis, Ann Surg Oncol, 3, 570, ; Tsuruta M. (2008), Heat shock protein 27 a novel regulator of 5-fluorouracil resistance in colon cancer, Oncol Rep, 20, 1165. ; Welch W. (1992), Mammalian stress response: Cell physiology, structure/function of stress proteins and implications for medicine and disease, Physiol Rev, 72, 1063. ; Xiang T. (2008), RNA interference-mediated silencing of the Hsp 70 gene inhibits human gastric cancer cell growth and induces apoptosis in vitro and in vivo, Tumor, 94, 4, 539.