The engine simulations have become an integral part of engine design and development. They are based on approximations and assumptions. The precision of the results depends on the accuracy of these hypotheses. The simplified models of frozen composition, chemical equilibrium and chemical kinetics provide the compositions of combustion products for engine cycle simulations. This paper evaluates the effects of different operating conditions and hypotheses on the exergetic analysis of a spark-ignition engine. The Brazilian automotive market has the highest number of flex-fuel vehicles. Therefore, a flex-fuel engine is considered for simulations in order to demonstrate the effects of these different hypotheses. The stroke length and bore diameter have the same value of 80 mm. The in-cylinder irreversibility is calculated for each case at the closed part of the engine cycle. A comparative analysis of these hypotheses provides a comprehensive evaluation of their effects on exergetic analysis. Higher values of accumulated irreversibility are observed for the oversimplified hypothesis.